I have had CW2 hang three times now. In all cases nothing I did had any effect on the display: moving the mouse or pressing keys did nothing. (The mouse still moves however). Twice out of 3 times I heard the characteristic click sound when pressing the F2..F12 keys, even though the screens were not coming up.
Once I used the instructions in the stickied thread about restoring from a backup to get back.
I did set the mouse to hardware mode, I will try it in software mode, but I dobt that has an effect.
I believe in all cases this happened after I left the PC to go to sleep on its own and I came back and woke it up.