You learn more from making mistakes than from doing the proven. Besides, it can bee a hell-of-a-lot-fun if you can get away without getting bruised up too badly
That being said there are a couple of things you should be aware of:
- Fort Leavenworth KS is a strategic location. Always good to take them SL's.
- Once the Saint Louis Massacre has occurred, Saint Joseph MO will general be the only town in Missouri with enough loyalty for the Union to produce units (a faction needs =>25%).
- If a town, harbor, depot or Indigenous Peoples Community ( villages) has <50% loyalty to your faction, you cannot capture it with early war cavalry alone, although you can capture the region. You need at least 1 militia regiment which must remain inside the location for you to control it. Conscript infantry and better can control locations by just being in the region.
- If you do not control a location in which you have <=10% loyalty, the population can revolt and generate an enemy partisan unit.
- If you are using units with the raider/pillager ability (Rangers, Indians, etc), if you send them through an un-garrisoned location containing supplies, they will take what they can carry and destroy the rest. Not good if you are low on supplies. If you end their turn in such a location, they will just take what they need and leave the rest which then can be shared among your following units.
- With a probe into such relatively unimportant areas, you will not scare Athena as easily as you might a human opponent, who might not analyze exactly what the values of those locations are and only see rebels on the Missouri River
Have fun, but don't expect any radical influence on the game.