In case anybody wondered, I've tested PoN on Windows 8 Release Candidate (available for free download from somewhere in microsoft.com).
1) It works
2) This may be a problem of specific hardware... But it works better. My Radeon 5650 HD mobile gave me slideshow, I couldn't drop a factory where I wanted on any drivers and system options. Now framerate is far from perfect but it's defenitely playable. Enjoy!